Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu
By: Shargel, Leon
Contributor(s): Wu-Pong, Susanna. | Yu, Andrew B. C.Call number: QV38 S531A 2012 Material type: BookPublisher: New York : McGraw-Hill Medical, c2012 Edition: 6th ed.Description: xviii, 811 p. : ill., charts.ISBN: 9780071603935 (hbk.).Other title: Applied biopharmaceutics and pharmacokineticsSubject(s): Biopharmaceutics | Models, Chemical | Pharmacokinetics
Introduction to biopharmaceutics and pharmacokinetics -- Mathematical fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartment models: intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drub distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and In Vitro drug product performance -- Drug product performance, In Vivo: bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnological products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dose adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory -- Appendix A: Statistics -- Appendix B: Applications of computers in pharmacokinetics -- Appendix C: Solutions to frequently asked questions (FAQs) and learning questions -- Appendix D: Guiding principles for human and animal research -- Appendix E: Popular drugs and pharmacokinetic parameters.