Biotechnology and biopharmaceuticals : transforming proteins and genes into drugs / Rodney J.Y. Ho, Milo Gibaldi.
By: Ho, Rodney J. Y
Contributor(s): Gibaldi, MiloCall number: QV35 H678B 2013 Material type: BookPublisher: Hoboken, N.J. : Wiley-Blackwell, c2013. Edition: 2nd ed.Description: xxvi, 698 p. : ill., charts.ISBN: 9781118179796 (pbk.).Subject(s): Biopharmaceutics | Chemistry, Pharmaceutical | Drug design
Introduction to biopharmaceuticals -- Distinctions of biologic versus small molecule platforms in drug development -- Financing biologic drug development -- Application of biotechnology in drug discovery and early development -- Large-scale production of recombinant proteins -- Clinical pharmacology, toxicology, and therapeutic dosage and response -- Clinical evaluation and regulatory approval and enforcement of biopharmaceuticals -- Pharmacoeconomics and drug pricing (Garrison*) -- Antibodies and derivatives -- Hematopoietic growth and coagulation factors -- Cytokines and interferons -- Hormones -- Enzymes -- Vaccines (Hu, Ho*) -- Other biopharmaceutical products -- Advanced drug delivery -- Advances in personalized medicine: pharmacogenetics in drug therapy -- Gene and cell therapy -- Integration of discovery and development: the role of genomics, proteomics, and metabolomics -- Pharmacoeconomics, outcome, and health technology assessment research in drug development -- Future prospects -- Appendix I: Dosage form, pharmacokinetics, and disposition data -- Appendix II: Molecular characteristics and therapeutic use -- Appendix III: Nomenclature of biotechnology products -- Appendix IV: Other information.