Introduction to drug disposition and pharmacokinetics / Stephen H. Curry, Robin Whelpton.
By: Curry, Stephen H.
Contributor(s): Whelpton, Robin.Call number: QV38 C976I 2017 Material type: BookPublisher: Chichester, U.K. : John Wiley & Sons, 2017Description: xi, 323 p. : ill., charts.ISBN: 9781119261049 (pbk.).Subject(s): Pharmacokinetics | Biopharmaceutics | Pharmaceutical preparations -- Metabolism
Introduction: basic concepts -- Drug administration and distribution -- Drug metabolism and excretion -- Single-compartment pharmacokinetic models -- Multiple-compartment and non-compartment pharmacokinetic models -- Kinetics of metabolism and excretion -- Clearance, protein binding and physiological modelling -- Quantitative pharmacological relationships -- Pharmacokinetics of large molecules -- Pharmacogenetics and pharmacogenomics -- Additional factors affecting plasma concentrations -- Effects of age and disease on drug disposition -- Drug interactions and toxicity -- Perspectives and prospects: reflections on the past, present and future of drug disposition and pharmacokinetics.